There are many cases where patients experience fatigue for a very long period of time without knowing the actual cause. Several people see dozens of doctors, go to many hospitals but still fail to pinpoint the problem. Some patients do not have any secondary illnesses and at the same time get adequate rest, yet the fatigue remains. These category of patients are normally diagnose with Chronic Fatigue Syndrome (CFD). Apart from the severe fatigue, symptoms may include muscle pain, joint pain, sore throat, pain around the lymph node or neurological symptoms such as insomnia and amnesia.

People with chronic fatigue may have the following conditions: anxiety, depression, chemical allergies and irritable bowel syndrome. 

     The abovementioned shows an imbalance in the body’s various systems which are connected to each other. For example, the brain (mind), nervous system, immune system and endocrine system is what we call the Psycho Neuro Immuno Endocrine (PNIE). Limbic System is the part of the brain that acts as a controller. This part of the brain plays an important role in controlling emotions, behaviors, movement, senses, long-term memory plus the production of hormones.

     In order to understand the cause of chronic fatigue, we should understand the mechanism of energy generation at the cell level. Normally, each cell needs energy in various processes, such as protein synthesis, hormone production, enzyme production, neurotransmitter production and also the elimination of waste from the cells. The energy that is used is in the form of ATP, which is produced within the cell. The energy-generating factory in the cell is called Mitochrondria. The food and oxygen that are used to grow the cells are brought into this factory and converted to energy (ATP). 

     The mechanism for energy generation is a complex chemical process that relies on vitamins, minerals, amino acids, and various types of enzymes. Another important step is the chemical process called Krebs Cycle or Citric Acid Cycle. 80% of the oxygen we breathe will be used in the energy generation process of Krebs Cycle.

     The Krebs Cycle consists of 8 steps, like a car with an 8-piston engine. If any piston is jammed, the engine will have a problem. Another factor that obstructs the energy generation is the accumulation of heavy metals in the body (heavy metals are substances that are 5 times heavier than water with the same volume). There are many different types of toxic heavy metals, such as arsenic, lead, mercury, and cadmium. According to toxic ranking in a human body, arsenic is ranked in the 1st place, followed by lead in 2nd place, mercury in 3rd place, and cadmium in 7th place. They are all heavy metals.

     These substances will obstruct the function of various steps of the Kreb Cycle and halt the energy generation process, which is like a piston being obstructed by dirt in an engine. The cells will lack energy and degenerate. In addition the body will become fatigued. Therefore, heavy metals is another factor causes chronic fatigue. 

     To check for an abnormal Kreb Cycle, urine is collected to check for the organic compounds that come from the energy generation process know as Urine Organic Acids. This allows patients to pinpoint the problem and how to resolve it so that the energy generation process can be completed. The heavy metals in the body can be excreted by a therapeutic therapy called Chelation. The procedure consist of an intravenous administration of saline solution with several types of amino acids that attaches with the heavy metals accumulated in various tissues in the body. It will then drive the heavy metals out through the kidneys. The urine will then be kept for 6 hours. This process is called the Urine Challenge Test. It will allow patients to know which types of heavy metals and how much have accumulated in the body, in order to help plan further treatments.